Crystallin promoter

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August undefined, 2024

WebRetrospectively from the results of ( Maf) knock-out mice. it was also shown that MAF binds the promoter sequences of some, B-crystallin promoters ( Ring et al., 2000 ). Three … WebNov 3, 2003 · In order to identify PaxB response elements in the J3-crystallin promoter, we generated a series of J3 promoter deletions in the luciferase reporter construct. The shortest promoter fragment, consisting of only 200 bp upstream of the transcriptional start site, was activated by PaxB and not by PaxB(I84R) (data not shown; but cf. Figure 5C ) .

Delta Crystallin - an overview ScienceDirect Topics

WebDec 1, 2012 · The gene promoter contains response elements for some key transcription factors essential for normal lens development. Prominent among these are factors such as Pax6, c-Maf, Sox2, Prox1, and Six3 [93,94]. In many crystallin gene promoters, elements for lens and non-lens expression are combined in the same 5 ′ region. WebMar 30, 2024 · Stimulation of αA-crystallin promoter activity via 8-bromo-cAMP, forskolin, or human T-cell leukemia virus type I Tax1 in transfections and reduction of activity of this site in cell-free transcription tests by competition with the somatostatin CRE supported the idea that DE1 is a functional CRE. Finally, Pax-6, a member of the paired-box ... green bay packer colors

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WebDec 1, 2012 · In many crystallin gene promoters, elements for lens and non-lens expression are combined in the same 5 ′ region. However, one of the more recently … WebBy use of a gene fusion of the alpha A-crystallin promoter to the viral immortalizing oncogene, polyoma large T antigen (PyLT), we created transgenic mice that express PyLT specifically in ocular lens. Expression of large T antigen during embryonic development led to a perturbation in lens development, specifically, an interference with the ... WebI am a highly motivated and passionate individual with a talent for organization and project management. I have enjoyed leading teams to complete projects in various industries … flower shop katy texas 77494

Epigenetic Regulation of αA-crystallin in High Myopia-Induced …

Delta Crystallin - an overview ScienceDirect Topics

WebThe same SOX proteins also regulate γ-crystallin genes. the mammalian counterpart of δ crystallin. A conserved and essential DNA motif in the promoters of the γ-crystallin genes is the binding site of the SOX proteins that activate the promoters (Kamachi et al., 1995). SOX1 strongly, and SOX2 and SOX3 modestly, activate these crystallin ... WebA DCR1/αA-crystallin promoter (including DCR2) coupled with EGFP virtually recapitulated the expression pattern of αA-crystallin in lens epithelium and fibers. In contrast, the DCR3/αA/EGFP reporter was expressed only in 'late' lens fibers. Chromatin immunoprecipitations showed binding of Pax6 to DCR1 and the αA-crystallin promoter … flower shop kennett square paWebWe have further compared the γD-crystallin promoter with the γB-crystallin promoter, the promoter with the most extended developmental expression. We show that the γ … green bay packer cotton fabric

"WebFGF2 strongly activates expression of the αA-crystallin gene promoter coupled with the DCR1 enhancer compared to the promoter alone. 234 Interestingly, FGF signaling also regulates expression of a large set of miRNAs that modulate gene expression during FGF2-induced lens fiber cell differentiation. 157 At least three miRNAs, including miR-143 ... " - Crystallin promoter

Crystallin promoter

The human crystallin gene families - PMC - National Center for ...

WebCrestline serves sophisticated institutions, family offices and high-net-worth individuals in North America, Europe and Asia who seek innovative alternative investment solutions … WebProx1 activates several of the different crystallin promoters, and acts synergistically with another lens transcription factor, Maf, to activate transcription of ß1 and ß2 crystallins (Lengler ...

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WebApr 8, 2024 · Among the 14 crystallin genes that human and mouse have in common, mRNA levels of Crybb1, Crygd, Cryba2, Cryba4, Crybb3, Cryga, and Crygs were significantly up-regulated in myopic eyes of... WebThe inclusion of a Pax6 consensus binding site within the -282/+43 alphaA-crystallin promoter enhances the ability of this promoter to drive transgene expression in the lens …

WebJul 15, 1992 · Progeny from two of these lines were mated with transgenic mice expressing the Cre recombinase under control of either the murine alpha A-crystallin promoter or … WebPromoter methylation of RASEF was associated with increased risk of death due to metastasis, ... Epigenetic regulation of αA-crystallin in high myopia-induced dark nuclear cataract. PLoS One 2013; 8: e81900. doi: 10.1371/journal.pone.0081900. 8. Mao W, Rubin JS, Anoruo N, Wordinger RJ, Clark AF.

WebRegulation of Mouse Small Heat Shock Protein alpha b-Crystallin Gene by Aryl Hydrocarbon Receptor. Author: Liu, S. A. L. S. A. Piatigorsky, J. Author Address WebLens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic …

Webgene-specific sequences such as the gene-specific promoter sequence in the proximal promoter of the small heat shock protein gene, alpha B-crystallin (cryab) , may have critical roles in regulating gene-specific activity from eukaryotic promoters. AlphaB-crystallin is a novel regulator of brain metastasis in triple-negative breast cancer.

WebSox-1 transactivated the γF-crystallin promoter in a dose-dependent fashion, similar to c-Maf (Fig. 2 C). Sox-1 also stimulated the βB2 promoter, but less strongly than c-Maf (Fig. 2 B). Prox-1 (80 ng) stimulated the βB2- and γF-crystallin promoters only about 2-fold (Fig. 2, B and C). To determine whether these transcription factors can ... flower shop keene nhWebMay 4, 2006 · Dramatic upregulation of αA-crystallin expression is associated with primary lens fiber cell differentiation. Previous studies have shown that a −366 to +46 αA … flower shop joplin moWebFeb 21, 2024 · The predicted promoter probability and location, and the type of the mutation are shown above each sequence (TSS at position 100). b–d, TERT promoter point mutations predicted by the CNN model... flower shop katy txWebJul 5, 2002 · Crystallin promoter reporters. The constructs with the αA-, βB2-, and γF-crystallin promoters linked to a luciferase reporter are depicted. Potential c-Maf recognition sites are located at −110 to −98 in the αA and βB2 promoters, and at −47 to −35 in the γF promoter ( 30, 31, 32 ). flower shop kenu inWebCrystallins are a diverse group of abundant soluble proteins that are responsible for the refractive properties of the transparent eye lens. We showed previously that Pax-6 can activate the αB-crystallin/small heat shock protein promoter via the lens-specific regulatory regions LSR1 (−147/−118) and LSR2 (−78/−46). flower shop kemptville ontarioWebSome articles on promoter, crystallin promoter: Perlecan - Expression - Signaling Pathways and Their Effect On Expression - Transcriptional Activation The upstream 2.5 … flower shop kent waWebFeb 21, 2024 · The sequence between SacI and AfeI was replaced with a sequence containing CG-depleted chicken lens δ1-crystallin gene (Sasaki) promoter 51, a … green bay packer crafts