Web15 ott 1990 · In addition, a tripeptide containing dolavaline, valine and dolaisoleucine with all asymmetric carbons identical configurationally to those in dolastatin 10 was found to be about 30% as effective as dolastatin 10 in inhibiting tubulin polymerization. Cytotoxic effects were much more sensitive to alterations in the dolastatin 10 structure. WebDolastatin 10 is a linear peptide composed of four amino acids: dolavaline, valine (Val), dolaisoleuine (Dil) and dolaproine (Dap) plus the C-terminal amine dolaphenine (Doe).
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WebDolastatin 10 is one of a number of potent cytotoxic natural products that have been isolated from the marine sea hare Dolabella auricularia. The chemistry and biology of the dolastatins were the subjects of a recent comprehensive review (Poncet, 1999).The compound is a linear pentamer (Fig. 5) that includes four amino acids unique to the … Web27 nov 2013 · Below the dolastatin 10 seed another analog resolved with m/z=761; it also bore an additional CH 2 on Dolavaline or Val, but showed a fragment for the rest of the molecule that was 38 Da lighter ... birthday flowers for delivery tomorrow
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Web1 apr 2000 · Structurally, it consists of four amino acids (dolavaline, valine, dolaisoleuine, and dolaproine), three of which are unique, linked to an unusual primary amine (dolaphenine) at its COOH terminus (Fig. 1; Ref. 1). Subsequently, the absolute configuration of its nine asymmetric centers was established, and total synthesis was … Web15 ott 1990 · Dolastatin 10 consists of four amino acids (in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine), three unique to D. auricularia, linked … WebThe antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15, although potently cytotoxic, is a relatively weak inhibitor of tubulin assembly and does not inhibit the binding of any other ligand to tubulin. The only methodology foun … dank of england death