Webb17 apr. 2024 · Sodium azide is a toxic compound that is commonly used as a preservative. In flow cytometry, sodium azide helps to prevent capping and internalization of antigens and antibodies, which can both cause a decrease in signal. Additional resources Fundamentals of Flow Cytometry Webb14 juli 2006 · Long-term use of 3′-azido-3′-deoxythymidine (AZT) ... is close to these serum concentrations and suggests that AZT inhibition of thymidine phosphorylation could play a role in the clinical toxicity observed in AZT monotherapy. ... Physiological concentrations of purines and pyrimidines. Mol Cell Biochem, 140 (1994), ...
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WebbIntroduction. Hematological and immunological reference intervals play a critical role as clinical guides in the diagnosis or monitoring of several diseases as well as adverse reactions during clinical trials. 1,2 These parameters have been reported to vary by age, sex, pregnancy, dietary patterns, genetic background, and geographical factors. 3–5 For … Webb22 juli 2009 · For example, what’s the role of azide in AZT and its intramolecular interaction with the thymine and sugar moieties in AZT? In this study, electronic structural calculations of AZT are carried out, in comparison with simple organic azide compounds such as hydrazoic acid (HN 3 ) and methyl azide (CH 3 N 3 ), in order to reveal potential structural … setting your username in git
CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide …
Webb12 apr. 2024 · Lysosomal homeostasis and membrane maintenance involve ESCRT-dependent mechanisms, with protein ALIX playing a major role in lysosomal membrane repair. 44, 47, 77, 78 Thus, we tested whether ATG5 has an effect on ALIX recruitment to damaged lysosomes. In Huh7 ATG5-WT cells, ALIX puncta were induced and ALIX co … Webb14 apr. 2024 · Tumor-associated macrophages (TAMs)-based immunotherapy is a promising strategy. Since TAMs are mainly composed of M2-type macrophages, they have a promoting effect on tumor growth, invasion, and metastasis. M2-type macrophages contain a specific receptor CD163 on their surface, providing a prerequisite for active … WebbAzide-containing compounds have broad utility in organic synthesis and chemical biology. Their use as powerful tools for the labeling of biological systems in vitro has enabled insights into complex cellular functions. To date, fluorogenic azide-containing compounds have primarily been employed in the context of click chemistry and as sensitive … setting yourself up for success quotes