WebCannabis chemovars can be broadly categorized into 3 chemotypes: tetrahydrocannabinol (THC)-dominant, cannabidiol (CBD)-dominant, and THC/CBD-equivalent. 5 THC-dominant products are typically used for intoxication while CBD-dominant products, which are presumed not to be intoxicating, are prescribed for the treatment of epilepsy, anxiety, … WebTHC and CBD are both highly lipophilic and have poor oral bioavailability (estimated to be as low as 6%) [26, 27]. Oral THC formulations exhibit variable absorption and un-dergo extensive hepatic first-pass metabolism [28], resulting in lower peak plasma THC concentration relative to inhala-tion[29]andalongerdelay(~120min)toreachpeakconcen-
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Web(b) The possession of cannabis, useable cannabis, cannabis concentrates, and cannabis-infused products being physically transported or delivered within the state, in amounts not … Webknowledge about how THC concentration in cannabis affects the health and safety of consumers, and to produce this consensus statement. Our intent is to provide policy makers with a summary of evidence on topics of public health importance related to cannabis concentration. Research Context While more research is needed and research to date … Web92 TOMONOKI TATElSHl ETAL changcs in the activities and the contents of CYP isoenzymes ;ire reporled in hepatic microsomes of CC14-induced cirrhosis riits (Mtirrny tt N/.1987) or choline-deficient rats (Murray c't d. 1986). Although the same isocnzymes were not screened in t hose IWO studies ttncl cornparison could be difficult, their studies ancl … high low campers used